Presented here are several simple reactions monitored by 60 MHz process NMR performed in a 5 mm NMR tube.

Reaction #1: Acetic Anhydride in Water – Reacts to form Acetic Acid

NMR Monitored Reaction Profile

Reaction #2: Acetic Anhydride + Excess of Methanol + Acid – Yields Acetic Acid and Acetic Methyl Ester

First Reaction was Performed without Shaking the Sample before Observation

NMR Monitored Reaction Profile

Second Reaction was Performed with a vigorous shake of the NMR tube before observation.

NMR Monitored Reaction Profile

For More Information Contact John Edwards

These are non-spinning spectra obtained on a Qualion process NMR spectrometer operating at 58 MHz. The spec on water at this shim level is 1.5/5/20 Hz at 50%/10%/0.5% peak height. The first spectrum is of 91% isopropyl alcohol in water – store bought pharmacy product. The second spectrum shows the comparison of a 300 MHz 1H NMR spectrum of Advil compared to a non-spinning 58 MHz spectrum.

Presented on June 18, 2009
Philadelphia, PA

“Spectroscopy Based Crude Assays for Laboratory, At-Line, and On-Line Applications”

This Presentation can be found at the Crude Oil Quality Group Website (http://www.coqa-inc.org/061809Giammatteo.pdf)

Presented at Marist College, Poughkeepsie
September 23, 2009

A Self-Employed Application Chemists Odyssey in the World of Analytical Instrument Development The Viability of a $50K High Resolution NMR and $15K ESR Spectrometers

By John C. Edwards, Ph.D.
Process NMR Associates, LLC, Danbury CT

The availability of cheap commodity electronics developed for the cellular phone industry is revolutionizing the design of NMR and ESR spectrometers. Rather than instruments that fill half a room, cost $200-3,000K+, and intimidate users, it is possible to produce spectrometers that are an order of magnitude cheaper to produce. Examples of NMR and ESR spectrometer development projects will be described as well as the wide-ranging applications that these spectrometers can deliver to the areas or process control, food authentification and automated laboratory analysis.

John Edwards was born and raised in Bolton, UK. He graduated from the University of Durham, UK with a B.Sc. in Chemistry in 1986. He obtained his Ph.D. in Physical Chemistry from the University of South Carolina in 1990, working on solid-state NMR applied to heterogeneous catalysts under the guidance of Professor Paul Ellis. From 1990-1997 he worked as a research chemist at the Texaco R&D facilityin Beacon, NY where he was responsible for global NMR support of upstream, downstream, and petrochemical Texaco ventures. In 1997 he formed Process NMR Associates which operates as a commercial analytical NMR spectroscopy service and consultancy. Process NMR Associates along with its engineering company partners, develops, markets, and supports on-line process NMR spectrometers utilized for control and optimization of refinery, petrochemical, pharmaceutical and food manufacturing operations. The company also acts as an application development company for several analytical instrument companies and supports the chemometric development of several process analytical products. He currently resides in Poughkeepsie, NY, with his wife and 3 sons. He is an affiliate professor of Chemistry at Marist College, a Research Associate at SUNY New Paltz, and an active member of the American Chemical Society.

A copy of the presentation can be provided on request… contact John Edwards if interested.

Topnir Systems is proud to announce the signature in October 2009 of a Partnership Agreement with Process NMR Associates, LLC.

This partnership enables Process NMR to utilize our field proven software in complementary fields NMR and MIR combining forces to deliver total solutions with increased added value to customers.

Topnir Systems is a French company leader in the field of online Near InfraRed (NIR) analyzers. Topnir enables measuring and monitoring multiple hydrocarbon streams in less than one minute using a single online system. The company has a long history in the refining and petrochemicals business, being the first world wide to implement an online application designed to measure and control octane number for gasoline production, first NIR on-line application worldwide on Ethylene Plant Naphtha feed (1986), Gasoline (1989) and Crude (1991). The business started in the late 80s within BP Oil, with applications development around gasoline and diesel blending, as well as FCC, CDU, Reformer and Ethylene plant feed andproducts characterization. Major oil companies such as Shell, BP, Repsol, Aramco… have adopted Topnir solutions.

Topnir has recently expanded its activities to provide platform independent software for NIR systems already installed in the field. Topnirs modeling technology offers a full set of properties from a single model which offers the advantage of a robust, reliable system requiring very light maintenance. In addition Topnir is field proven to have ASTM and better results.

Process NMR Associates, LLC is an American company and leader in the field of online Nuclear Magnetic Resonance (NMR) process applications. The company also has a long history in the refining and petrochemicals business, being the first world wide to implement online NMR applications for gasoline and diesel blending, FCC, CDU, Reformer and Ethylene plant feed and products characterization.

Topnir Systems
425, rue RenéDescartes
Espace Descartes, Bat C
Parc de la Duranne
13857 Aix-en-Provence, France
Tel +3350 73 47 / Fax+3350 73 50
Web: www.topnir..com
USA Contact: Julie Williams Tel: +1-508-736-2696

Process NMR Associates, LLC
87A Sand Pit Road
Danbury, Connecticut 06810 USA
Tel +203-744-5905
Fax +203-743-9297
Web: www.process-nmr.com
Contact: Dr. Paul Giammatteo