Reaction Monitoring by Process NMR

Presented here are several simple reactions monitored by 60 MHz process NMR performed in a 5 mm NMR tube.

Reaction #1: Acetic Anhydride in Water – Reacts to form Acetic Acid

NMR Monitored Reaction Profile

Reaction #2: Acetic Anhydride + Excess of Methanol + Acid – Yields Acetic Acid and Acetic Methyl Ester

First Reaction was Performed without Shaking the Sample before Observation

NMR Monitored Reaction Profile

Second Reaction was Performed with a vigorous shake of the NMR tube before observation.

NMR Monitored Reaction Profile

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