• Skip to main content
  • Skip to primary sidebar

NMR Testing Laboratory

Industrial NMR Spectroscopy Applications

  • Home
  • About Us
    • About Process NMR
    • Our History
    • Facilities
    • Applications
    • Chemometrics
    • News and Events
  • Services
    • Price List
    • Submission Form
    • Liquid NMR
    • Solid NMR
    • Benchtop NMR
    • Consulting
    • Automated Applications
    • Expert Witness
  • Expertise
    • CV
    • Presentations
    • Reviews and White Papers
  • Blog
  • Contact
You are here: Home / Archives for Herbal Supplement

PNA to Present 4 Topics at the 2015 ACS North East Regional Meeting

May 17, 2015 by process nmr Beer, Benchtop NMR, Chemometrics, Cider, Energy, Herbal Supplement, NMR, PAT, Petroleum, qNMR

John Edwards of Process NMR Associates will be presenting 4 papers at the 2015 ACS Northeast Regional Meeting that will be held in Ithaca, NY, June 10-13, 2015.

ABSTRACT ID: 2283171
ABSTRACT TITLE: 1H qNMR of Alcoholic Cider – Analysis of Small Molecule and Residual Sugar Chemistry (final paper number: 43)
SESSION: Food Chemistry
SESSION TIME: 5:00 PM – 9:00 PM
PRESENTATION FORMAT: Poster
DAY & TIME OF PRESENTATION: Wednesday, June, 10, 2015, 5:00 PM – 9:00 PM
ROOM & LOCATION: Emerson Suites – Campus Center

ABSTRACT ID: 2283063
ABSTRACT TITLE: Nutritional Supplement and Diesel Fuel Application Development for Benchtop NMR Systems Operating at 42, 60, and 80 MHz – Equivalency with Supercon NMR (final paper number: 336)
SESSION: Analytical Chemistry
SESSION TIME: 9:00 AM – 11:30 AM
PRESENTATION FORMAT: Oral
DAY & TIME OF PRESENTATION: Friday, June, 12, 2015 from 9:45 AM – 10:05 AM
ROOM & LOCATION: 222 – Williams Hall

ABSTRACT ID: 2283105
ABSTRACT TITLE: Survey of Low Field NMR Spectrometer Platforms for Successful Screening of Sexual Enhancement and Weight Loss Supplements for Adulteration with Drugs and Drug Analogs (final paper number: 386)
SESSION: Medicinal Chemistry
SESSION TIME: 1:00 PM – 3:20 PM
PRESENTATION FORMAT: Oral
DAY & TIME OF PRESENTATION: Friday, June, 12, 2015 from 2:20 PM – 2:40 PM
ROOM & LOCATION: 302 – Williams Hall

ABSTRACT ID: 2283153
ABSTRACT TITLE: From Mash to Bottle: Chemistry of the Beer Brewing Process and NMR-based Quality Control (final paper number: 284)
SESSION: Food Chemistry
SESSION TIME: 1:30 PM – 3:10 PM
PRESENTATION FORMAT: Oral
DAY & TIME OF PRESENTATION: Thursday, June, 11, 2015 from 1:35 PM – 1:55 PM
ROOM & LOCATION: 202 – Williams Hall

Benchtop NMR – Screening Tool for Adulterated Herbal Supplements

February 26, 2015 by process nmr Benchtop NMR, Chemistry, Herbal Supplement, NMR

Survey of Low Field NMR Spectrometer Platforms for Successful Screening of Sexual Enhancement and Weight Loss Supplements for Adulteration with Drugs and Drug Analogs

John C Edwards1, Kristie M Adams2, and Anton Bzhelyansky2

1Process NMR Associates, Danbury, CT
2United States Pharmacopeial Convention, Rockville, MD

The adulteration of dietary supplements (or natural health products) with synthetic pharmaceuticals is an area of increasing concern, which presents substantial risk to public health. Widely available in retail and via the Internet, these products are often marketed as sexual enhancement, weight loss and/or bodybuilding supplements. Unlike prescription drugs, supplements do not require premarket approval by FDA before they are made available for public consumption. In fact, the agency can only take investigational action after the adulterated product has caused harm and the adverse event has been reported via MedWatch (FDA’s online portal for voluntary reporting of adverse events associated with drugs, medical devices and dietary supplements).
Development of analytical tools for screening and identification of adulterated products in the marketplace represents a significant step forward in the fight against adulterated dietary supplements. Several organizations, including AOAC and USP, have undertaken initiatives to evaluate and recommend analytical methodologies for screening supplements for adulteration. HPLC and mass spectrometry have so far dominated the screening and quantitation studies published in the literature, with NMR spectroscopy often relegated to the status of structure elucidation tool. In this work, we investigate the ability of several-low field NMR spectrometric platforms to successfully identify and quantify the presence of adulterating drug substances in sexual enhancement and weight loss supplements purchased online and in US retail. 1H qNMR of both types of samples was performed with 300 MHz NMR to confirm the presence of adulterants such as sildenafil, tadalafil, and their structural analogues (sexual enhancement supplements) and various synthetic stimulants (weight loss supplements). We have concluded that a simple sample preparation protocol combined with straightforward 1H NMR spectroscopic analysis yields a rapid, robust and reliable screening test for adulterated supplements, presenting an attractive alternative to more labor-intensive, expensive and expertise-demanding techniques du jour.

This was presented by John Edwards at SMASH in September 2014, and at the Carolina NMR Symposium in November 2014

presentation can found here: Benchtop NMR – Herbal Supplement Adulteration Screening

43 MHz - 1H NMR - Benchtop Analysis of Contamination of herbal supplements with PDE5 inhibitors
43 MHz – 1H NMR – Benchtop Analysis of Contamination of herbal supplements with PDE5 inhibitors
300 MHz - 1H NMR - Benchtop Analysis of Contamination of herbal supplements with PDE5 inhibitors
300 MHz – 1H NMR – Benchtop Analysis of Contamination of herbal supplements with PDE5 inhibitors

Nutritional Supplement and Diesel Fuel Application Development for Benchtop NMR Systems Operating at 42, 60, and 80 MHz – Equivalency with Supercon NMR

February 26, 2015 by process nmr Benchtop NMR, Chemometrics, Energy, Herbal Supplement, NMR, PAT, qNMR

Benchtop high-resolution NMR systems are available at a number of field strengths and probe configurations. However beyond the obvious academic instruction market for these instruments very few applications have been demonstrated across all available platforms and thus proving the general applicability of benchtop NMR technology to industrial quality control. We will present two chemometric-based applications that have been developed at 4 different field strengths utilizing Varian Mercury 300 MHz, Magritek Spinsolve 42 MHz, Aspect AI 60 MHz, and Thermo Picospin 80 MHz NMR systems. Partial-least-squares (PLS) regression correlations were obtained on all 4 platforms relating to:
1) Omega-3 fatty acid composition of samples taken from various points in a nutritional supplement manufacturing process. Excellent correlations were obtained on all 4 NMR instruments proving that NMR technology is applicable to in-lab, at-line. or on-line analysis of fish oil derived omega-3 fatty acid supplements. The 40 second NMR analysis effectively replaces a 60+ minute GC analysis.
2) Physical and chemical property determination of diesel fuels where excellent correlations were obtained between 1H NMR variability and parameters such as density, aromatic content by GC, hydrogen content by 1H TD-NMR (ASTM D7171 method), and sulfur content. Many more physical and chemical properties can be correlated to the 1H NMR spectrum allowing a single 40 second NMR experiment to predict 10-15 parameters that each require dedicated analyzers.
Finally, we will present the concept and initial results from an independent server-based NMR application software that can be utilized in conjunction with the NMR software of the current benchtop NMR systems, or alternatively as a stand-alone application platform. This software would effectively make chemometric and direct measurement NMR application ubiquitous across all NMR platforms.

A link to this presentation in PDF form is given here: PLS-Regression – 300_80_60_43 MHz NMR of Fish Oil Supplements and Diesel Fuel

Presentations at SMASH 2014

September 11, 2014 by process nmr Beer, Chemistry, Chemometrics, Herbal Supplement, Process NMR, qNMR, Reaction Monitoring

“Beer Manufacturing and Analysis by NMR”, John C. Edwards and Adam Dicaprio, Presented at the Mestrelab MNova Users, Meeting – SMASH, Atlanta, GA, September 7, 2014
Get PDF Here

“Survey of Low Field NMR Spectrometer Platforms for Successful Screening of Sexual Enhancement and Weight Loss Supplements for Adulteration with Drugs and Drug Analogs”, John C. Edwards, Kristie Adams, Anton Bzhelyansky , Presented at SMASH Conference, Atlanta, GA, September 7-10, 2014.
Get PDF Here

Presentation and Posters – Magnetic Resonance in Food Conference 2014 – Cesena Italy

September 11, 2014 by process nmr Chemistry, Chemometrics, Herbal Supplement, NMR, qNMR

“Liquid and Solid-State 27Al qNMR of an Elemin Senonian Trace Minerals Supplement for Identification, Chemical Structure, Quantitation of Active Ingredient in the Product, and Product Stability”, Boris Nemzer, John C. Edwards, presented at XII International Conference on the Applications of Magnetic Resonance in Food Science: Defining Food by Magnetic Resonance, Cesena, Italy, May 20-23, 2014.
Get PDF Here

“Liquid and Solid-State Multinuclear 13C and 11B qNMR FruitexB Fructoborate Complex Nutritional Supplement. Identification, Chemical Structure, Quantitation of Active Ingredient in Product, and Product Stability”, Boris Nemzer, John C. Edwards, presented at XII International Conference on the Applications of Magnetic Resonance in Food Science: Defining Food by Magnetic Resonance, Cesena, Italy, May 20-23, 2014.
Get PDF Here

“1H qNMR of EPA and DHA Omega-3 Fatty Acid Esters – PLS Regression Models Obtained by 60 and 300 MHz NMR – At-Line and On-Line Monitoring of a Fish Oil Nutritional Supplement Manufacturing Process”, John C. Edwards, Paul J. Giammatteo, invited oral presentation at XII International Conference on the Applications of Magnetic Resonance in Food Science: Defining Food by Magnetic Resonance, Cesena, Italy, May 20-23, 2014.

“Application of High Field and Cryogen-Free Bench-Top NMR Platforms to the Monitoring and Quantitation of PDE5 Inhibitor Adulteration of Male Sexual Enhancement Supplements”, John C. Edwards, Paul J. Giammatteo, Kristie Adams, Anton Bzhelyansky , presented at XII International Conference on the Applications of Magnetic Resonance in Food Science: Defining Food by Magnetic Resonance, Cesena, Italy, May 20-23, 2014.
Get PDF Here

  • Go to page 1
  • Go to page 2
  • Go to page 3
  • Go to page 4
  • Go to Next Page »

Primary Sidebar

  • Home
  • About Us
    • About Process NMR
    • Our History
    • Facilities
    • Applications
    • Chemometrics
    • News and Events
  • Services
    • Price List
    • Submission Form
    • Liquid NMR
    • Solid NMR
    • Benchtop NMR
    • Consulting
    • Automated Applications
    • Expert Witness
  • Expertise
    • CV
    • Presentations
    • Reviews and White Papers
  • Blog
  • Contact

Categories

  • Beer
  • Benchtop NMR
  • Chemistry
  • Chemometrics
  • Cider
  • Craft Beverage
  • Energy
  • ESR
  • Herbal Supplement
  • IR-ATR
  • NIR
  • NMR
  • NMR Test Methods
  • NMR Validation
  • PAT
  • Petroleum
  • Process NMR
  • qNMR
  • Reaction Monitoring
  • TD-NMR
  • Uncategorized

Meta

  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

Follow Us

Follow us on social media to stay on track with the latest news.

Twitter
Facebook
RSS

Search

Blogroll

  • Carlos' NMR Software Blog
  • Mestrelab Blog – NMR Data Processing Software
  • NMR Wiki
  • Stan's NMR Blog
  • University of Ottawa – NMR Facility Blog
  • Home
  • About Us
  • Services
  • Expertise
  • Blog
  • Contact

Copyright © 2023 · Process NMR · All Rights Reserved.
Handcrafted with by Studiodog Group