NMR Testing Laboratory

Industrial NMR Spectroscopy Applications

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Beware of Adulteration of “Herbal Supplements” for Erectile Dysfuntion

by Herbal Supplement, NMR, qNMR

We recently performed an analysis of a competitive product for a company working on developing “herbal supplements” for erectile dysfunction. They ended up not paying for the analysis so we thought we would just publish it generically as a “point of interest”. It was described to us that the product worked incredibly well which immediately made it suspicious … NB: we didn’t actually try it out ourselves. The bottom line is that the product was not “herbal” at all .. it was thiosildenafil an analog of Viagra.

“Herbal Supplement”

Viagra

Stacked comparison plot.

COSY

Beware out there. If you are on alpha-blockers for heart condition and buy an innocent looking “herbal” for ED issues .. it may actually be pharmaceutical grade viagra with all the use warnings that go with it.

MestreLab MNova Users Meeting – SMASH 2013 – PNA NMR Presentation

by Chemistry, Chemometrics, Herbal Supplement, NMR, Process NMR, qNMR, Reaction Monitoring

“Utilization of MNova in a Commercial NMR Testing Laboratory for: 1) Development of Automated Quantitative Analysis Methods by Direct Internal Standard NMR Measurements, and 2) Pre-Processing of Large NMR Datasets for Chemometric Regression Analyses to Derive Chemical and Physical Properties” – presented by John Edwards at the MNova Users Meeting – SMASH 2013 – Santiago de Compostela, Spain, September 22, 2013
PDF of Presentation

Automated 1H qNMR analysis of complex mixtures – example of aloe vera powder 200x

Final automated analysis output for aloe vera analysis – assignments and quantitative output.

Chemometric analysis – spectrum processing and X-matrix preparation performed in MNova – ascii output imported into Eigenvector Research Solo for PLS regression or PCA analysis. Correlation of 1H NMR at 300 or 60 MHz with GC analysis of EPA and DHA content (wt%).