RSC Symposium on Reaction Monitoring by NMR and Vibrational Spectroscopy
The presentations from the RSC symposium have been posted for download the RSC site at:
http://www.rsc.org/ConferencesAndEvents/RSCConferences/Reaction/speakers.asp
COSA Xentaur Instrument Corporation and Process NMR Associates, LLC sign Application Development Agreement
COSA Xentaur Corporation, the company that specializes in high technology analyzers for a wide range of applications in petrochemical, energy, environmental, pharmaceutical, semiconductor and plastics industries, has joined with Process NMR Associates, LLC (PNA) as its application development partner for Cosa Xentaur’s new spectroscopy based products lines. Initial development will be a Time Domain Nuclear Magnetic Resonance (TD -NMR) to be introduced at PittCon 2011 in March.
COSA Xentaur is focused on providing innovative measurement solutions to a wide range of analytical and process applications. It is COSA Xentaur’s philosophy to supply industrial and laboratory users with cutting edge technology in a reliable and affordable instrument with full application engineering and service support.
PNA provides solution based applications for a wide range of spectroscopy platforms. These include on-line, at-line, and laboratory automated analyses that are utilized worldwide in petroleum refineries, petrochemical, chemical, and food manufacturing. “Process NMR Associates is pleased to form this partnership with COSA Xentaur,” said Paul Giammatteo, Operations Manager. “This commitment enables both companies to deliver incomparable, solution driven applications on quality instrument platforms to meet the changing needs of analytical laboratories in a number of industries.”
Reaction Monitoring Using NMR and Vibrational Spectroscopy – RSC Conference
Dr. John Edwards of Process NMR Associates will be attending an RSC sponsored one day symposium on “Reaction Monitoring Using NMR and Vibrational spectroscopy – An Industrial Perspective”. The meeting will be held at the Pfizer Research Center in Sandwich, Kent, UK on March 22, 2011. Dr Edwards will be presenting a poster entitled “Practical Applications of Compact High-Resolution 60 MHz Permanent Magnet NMR Systems for Reaction Monitoring and Online Process Control”. The abstract of the talk is presented below:
For the past two decades high resolution 1H NMR at 60 MHz has been utilized to monitor the chemical physical properties of refinery and petrochemical feed-streams and products. These approaches involve the use of partial least squares regression modeling to correlate NMR spectral variability with ASTM and other official test methods, allowing the NMR to predict results of physical property tests or GC analysis. The analysis is performed in a stop flow environment where solenoid valves are closed at the beginning of the NMR experiment. This approach allows up to 5 or 6 different sample streams to be sent to the sample in order to maximize the impact of the instrument. The current work with these permanent magnet NMR systems is to utilize them as chemistry detectors for bench-top reaction monitoring, mixing monitoring, dilution monitoring, or conversion monitoring. In the past use of NMR for these applications has been limited by the need to bring the “reaction” to the typical “superconducting” NMR lab. A compact high resolution NMR system will be described that can be situated on the bench-top or in the fume hood to be used as a continuous or stop-flow detector and/or an “in-situ” reaction monitoring system. The system uses a unique 1.5 Tesla permanent magnet with a simple flow cell and total system volumes of 2 to 5 ml depending on the length and diameter of the transfer tubing. Further, detection limits of analytes in the 200+ ppm range are possible without the use of typical deuterated NMR solvents. Analysis times of 5 to 20 seconds are also possible at flow rates of 5 to 20+ ml/minute. Reaction monitoring directly in standard 5 mm NMR tubes again using conventional (non-deuterated) reactants, solvents and analytes will also be described.
Details of the symposium and registration information can be found at the RSC website.
Process NMR Associates Expands and Updates NMR Testing Facilities
Process NMR Associates has just finished completion of a complete update and expansion of the NMR facilities at it’s Danbury CT location. The faithful Varian Unity-300 spectrometer has been replaced by a Mercury-300 VX spectrometer and a second 300 MHz Mercury Plus system has been installed. This second 300 MHz NMR includes PFG and an indirect detection probe. These instruments compliment a Varian UnityPlus-200 spectrometer equipped with a 7 mm Solid-State MAS probe for analysis of solid materials. The doubling of the liquid-state NMR capacity will allow rapid turnaround of all sample submissions and expand the experimental capabilities of the facility.
Process NMR Associates is a private corporation providing analytical NMR services and consulting since 1997. The NMR facility in Danbury includes two 300 MHz, one 200 MHz, and two 60 MHz high resolution NMR spectrometers. The facility also houses a 10mm, 18mm, and 40mm TD-NMR facility for relaxation studies. The company also has gas chromatography, micro-ESR, and FTIR-ATR capabilities. For details of the analytical services provided please contact John Edwards.