Reaction Monitoring Archives - Page 4 of 4

Newsflash: For Immediate Release – Process NMR Associates and Quantum Tessera Enter into Strategic Partnership

May 16, 2012 by process nmr NMR, PAT, Process NMR, Reaction Monitoring, TD-NMR

Process NMR Associates, LLC, Danbury, CT and Quantum Tessera Consulting, LLC, Collegeville, PA, USA

Process NMR Associates, LLC (LLC) and Quantum Tessera Consulting, LLC are pleased to announce they have entered into a Strategic Partnership. This partnership will leverage PNA’s experience applying magnetic resonance techniques to such processes as reaction monitoring, active ingredient quality control, and the petroleum industry. PNA’s MR expertise extends into time-domain NMR, low field high resolution NMR (60MHz and 300MHz) applications, and chemometrics. Quantum Tessera brings its knowledge and experience about large molecule process development. Together, Process NMR Associates and Quantum Tessera can deliver higher value to clients process and manufacturing problems.

Process NMR Associates and Quantum Tessera’s first project will be focused initially on NMR-based solutions for bioprocess monitoring and biofuel manufacture.

Dr. John Edwards, Principal and Manager of Analytical Services at PNA comments, “The combination of Quantum Tessera Consulting and PNA will allow both companies to expand their customer base and allow them to offer a wider range of robust and innovative solutions to our clients.”

Dr. Edward Zartler, CSO of Quantum Tessera, adds, “Process NMR associates has always led the field in NMR-based process analytics. This Strategic Partnership will result in synergies between our two companies, where the sum will be greater than the individual parts.”

About Quantum Tessera Consulting, LLC (http://www.quantumtessera.com): Quantum Tessera provides complete analytical solutions to its clients. While focused on NMR-based solutions, Quantum Tessera is focused on delivering the most appropriate solution to its customers. Quantum Tessera is focused on two major areas: Fragment-based Drug Discovery (FBDD) and Bioprocess Development.

About Process NMR Associates, LLC (https://process-nmr.com/): Process NMR Associates provides 1) 300 MHz analytical NMR services and consulting, 2) sales and marketing of the Aspect Italia 60 MHz high resolution NMR systems for process analytical and laboratory applications, and 3) marketing, sales, and applications for the Cosa-Xentaur SpinPulse TD-NMR spectrometer series.

The Power of MestReNova Data Processing and Analysis Applied to 60 MHz 1H NMR Real Time Reaction Monitoring

May 14, 2012 by process nmr NMR, Process NMR, Reaction Monitoring, TD-NMR

The data analysis capabilities of the MestReNova NMR software makes processing and analyzing complex reaction mixture data a snap! Stacked plots are quick and easy and the integration routines rapidly process the peak areas into reaction profiles. Further steps allow the exponential fitting of the reaction profiles to yield kinetic information. Here are a few examples of the data visualization and rapid reaction profiling on a 60 MHz 1H NMR series obtained every 10 seconds (1 pulse) over the course of 25 minutes – the reaction is the esterification of tert-butanol with acetic anhydride in the presence of acid.

1H NMR Superimposed Plot - Reaction Monitoring
Figure 1: Stacked Plot of the Aliphatic Region of the Spectrum with Reaction Chemistry Protons Identified

Stacked Plot - 1H NMR Spectra - Reaction Monitoring
Figure 2: Stacked Plot – Full Spectrum – Reaction Monitoring – 146 Spectra – 10 Seconds Apart

Stacked and Angled Stacked Plot - 1H NMR - Reaction Monitoring
Figure 3: Angled Stack Plot – Acetic Anhydride and tert-Butanol – Real Time Reaction Monitoring by 1H NMR at 60 MHz

Whitewashed Stacked Plot - 1H NMR Spectra - Aliphatic Region - Reaction Monitoring
Figure 4: Stacked and Whitewashed Plot of 1H NMR data at 60 MHz – Real Time Reaction Monitoring of Acetic Anhydride with tert-Butanol

Integrated Stacked Plot with Reaction Profiles Obtained from MNova Data Analysis
Figure 5: Data Analysis Tool and production of reaction profiles.

The MNova data analysis tools allow the user to integrate NMR reaction peaks and automatically plots and fits them to exponential time constants allowing detailed kinetics to be extracted rapidly and easily from the data. What used to take hours of lining up ascii spectra in excel or other software now literally takes seconds. The integration is segmented in such a manner that integrals can be made to track with shifting resonances, for example labile protons effected by pH.

The AspectItalia 60 MHz NMR system allows real time analysis of reactions with high S/N on single pulses. half height linewidths of 1-2 Hz (15-30 ppb) are possible on static reaction setups and 2-5 Hz (30 – 80 ppb) are possible with flowing reactions at rates of 1-20 ml/min.

The MNova software is becoming a standard NMR processing platform with many users worldwide. Fully functioning demos can be downloaded from the MestReLab research site at: http://mestrelab.com/software/mnova-nmr/

For further details contact John Edwards