60 MHz 1H NMR Reaction Monitoring
Below are a few further examples of acetylation reactions of acetic
anhydride with an excess of alcohol. The alcohols include tert-butanol and
Reaction 1: Acetylation of t-butyl alcohol with acetic anhydride in the presence of acid.
Reaction 2: Acetylation of Isopropanol
anhydride in the presence of acid.
Reaction 3: Methoxyacetone and hydroxylamine reaction in methanol to form an
Resolution of the methylenes in the methoxyacetone and the reaction product
is readily observed.
All the above experiments were performed in an NMR tube. We are currently
looking at the same reactions under flow conditions utilizing a HPLC pump
and PEEK tubing to transport sample to the NMR probe at 5 ml/min.
Contact John Edwards if you have
interest in permanent magnet NMR technology for reaction monitoring.